Yes. You have two options: 

  1. RTMP mode: via the "Stream" option
  2. Webcam mode: either via "External Video" or via NDI

Loola RTMP Mode:

Open the stream settings in vMix:

Copy and paste the RTMP URL and Key from the Loola Studio to vMix:

Configure the Quality/Encoder settings:

See recommended platform encoder settings here:
https://support.loola.tv/en/articles/3284585-rtmp-encoder-settings

Click the Stream button in vMix to start the preview in Loola:

Loola Webcam Mode

vMix External Video (virtual camera)

First, make sure that "vMix Video / Streaming" is checked in the vMix settings.
Note: in order to support vertical 1080p (720x1280) in Loola, set the output height in vMix to be equal or larger than 1280:

Next, click the "External" button in vMix:


Next, select vMix in Loola and set desired resolution:


Note: the integral vMix Virtual Camera driver support video only. To get audio out of vMix, see the NDI option below.

vMix and NDI:

The video/audio flow: vMix --> NDI --> Loola --> Social Platforms

Start by with enabling NDI output in vMix:

More details here:
https://www.vmix.com/help21/index.htm?SettingsOutputs.html


Next, run the NDI Virtual Input:


Next, configure NDI to show the vMix output.

Next, select NDI audio and video sources in Loola:

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