Yes. There are two ways to use XSplit with Loola:
Webcam mode
RTMP mode
RTMP Mode:
Set up new custom RTMP:

Set Encoder Parameters and your Loola RTMP Key + URL:

Set the x264/H.264 profile to "main" by entering "&ex:profile:main" in extra encoder parameters:

Also make sure to set keyframe every 2 seconds and Strict CBR mode.
See additional encoder parameters here:
https://www.xsplit.com/blog/how-to-specify-extra-encoder-parameters
Webcam Mode:
In Webcam mode you will use the XSplit built-in Virtual Camera (XSplitBroadcaster).
Note: XSplit only output video to its virtual camera. Capturing audio directly from XSplit requires to setup a Virtual Cable (Windows) or Soundflower (Mac).
Selecting the XSplit virtual camera in Loola is done through the video/audio sources menu:

Setting portrait output resolution:
In order to work with Portrait resolutions, you will need to add those resolutions first in XSplit:


Next, select the newly added resolution:

In Webcam mode, make sure to select the new resolution in Loola:
