Yes.
The preferred way to use XSplit with Loola is via RTMP mode:
Select RTMP mode in Loola:
You should find your RTMP Key and Server URL:
In XSplit, set up new custom RTMP:
Set Encoder Parameters and your Loola RTMP Key + URL:
Set the x264/H.264 profile to "main" by entering "&ex:profile:main" in extra encoder parameters:
Also make sure to set keyframe every 2 seconds and Strict CBR mode.
See additional encoder parameters here:
https://www.xsplit.com/blog/how-to-specify-extra-encoder-parameters
Setting portrait output resolution in XSplit:
In order to work with Portrait resolutions, you will need to add those resolutions first in XSplit:
Next, select the newly added resolution:
