Yes. Using XSplit with Loola is done through the XSplit built-in Virtual Camera (XSplitBroadcaster).

Note: XSplit only output video to its virtual camera. Capturing audio directly from XSplit requires to setup a Virtual Cable (Windows) or Soundflower (Mac).

Selecting the XSplit virtual camera in Loola is done through the video/audio sources menu:

In order to work with Portrait resolutions, you will need to add those resolutions first in XSplit:

Next, select the newly added resolution:

Lastly, select the new resolution in Loola:

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