You can use OBS with Loola is two mode:

  1. Webcam mode: by installing a virtual camera 
  2. RTMP mode: by streaming RTMP directly from OBS to the Loola servers

RTMP mode enables greater stability, quality and control over the stream parameters, while Webcam mode is more suitable for limited network bandwidth scenarios. 

RTMP Mode:

See:
https://support.loola.tv/en/articles/3395558-how-to-configure-obs-in-rtmp-mode

Webcam Mode:

Windows

There are two ways to redirect the OBS video and audio to a virtual camera device under windows:
Method #1 - Using NDI Tools
Method #2 - Using Virtual Camera & Cable

After installing the plugins, simply select the virtual cameras as the video source to Loola.

MacOS

OBS doesn't have a virtual camera plugin on Mac. In order to get virtual camera in Mac, you will need to use CamTwist.
The idea is to capture the OBS video in CamTwist, and then select the CamTwist virtual camera in Loola.

Please see following guide for detailed setup instructions:
https://www.rightpoint.com/thought/2017/12/19/improving-your-video-meetings-on-skype-with-green-screens

Please see the CamTwist FAQ on how to set the CamTwist webcam driver resolution:
http://camtwiststudio.com/support/faq/

If you run into any issue, the following thread may help:
https://obsproject.com/forum/threads/virtual-web-cam-solution-for-mac.93632/

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